Kinematics describes how a particle moves along a line. Displacement, velocity and acceleration are vectors: choose one direction as positive and give the opposite direction a minus sign. Distance and speed are scalars and are never negative.
On a displacement–time graph the gradient is the velocity. On a velocity–time graph the gradient is the acceleration and the area under the graph is the displacement.
If the acceleration is constant, use the constant acceleration formulae. If s or v is given as a function of t, the acceleration is usually not constant, so you must differentiate or integrate instead.